Dr Samuel Cahill

Samuel Cahill
samuel.cahill@chem.ox.ac.uk
Phone: 
01865 281506
Chemistry
Lecturer in Physical Chemistry

Qualifications

MSc MA (Cantab), DPhil (Oxon)

Academic Background

Lecturer in Physical Chemistry, Christ Church, Oxford (2019 - )
Departmental Lecturer in Practical Chemistry, Dept. Chemistry, Oxford (2018 – )
Senior Demonstrator and Course Developer, Dept. Chemistry, Oxford (2017 – 2018)
Keble College, Oxford; DPhil (2013 – 2017)
Robinson College, Cambridge; BA MSc (2009 – 2013)

Undergraduate teaching

Physical & Biophysical Chemistry

Research Interests

Enzyme structure & mechanism. Chemical education & teaching practice.

Publications include:

Cahill, S. T., Tyrrell, J. M., Hopkins Navratilova, I., Calvopiña, K., Robinson, S. W., Lohans, C. T., McDonough, M. A., Cain, R., Fishwick, C. W. G., Avison, M. B., Walsh, T. R., Schofield, C. J., Brem, J. Studies on the Inhibition of AmpC and Other β-Lactamases by Cyclic Boronates. Biochim Biophys Acta Gen Subj. 2019

Zhang, D., Markoulides, M. S., Stepanovs, D., Rydzik, A. M., El-Hussein, A., Bon, C., Kamps, J. J. A. G., Umland, K. D., Collins, P. M., Cahill, S. T., Wang, D. Y., von Delft, F., Brem, J., McDonough, M. A. & Schofield, C. J. Structure Activity Relationship Studies on Rhodanines and Derived Enethiol Inhibitors of Metallo-β-Lactamases. Bioorg. Med. Chem. 2018

Cain, R., Brem, J., Zollman, D., McDonough, M. A., Johnson, R. M., Spencer, J., Makena, A. Abboud, M. I., Cahill, S., Lee, S.Y., McHugh, P.J., Schofield & C. J., Fishwick C. W. G. In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors. J. Med. Chem. 2018

Lohans, C. T., Wang, D. Y., Jorgensen, C., Cahill, S. T., Clifton, I. J., McDonough, M. A., Oswin, H. P., Spencer, J., Domene, C., Claridge, T. D. W., Brem, J. & Schofield, C. J. 13C-Carbamylation as a Mechanistic Probe for the Inhibition of Class D β-Lactamases by Avibactam and Halide Ions. Org. Biomol. Chem. 2017

Cahill, S.T., Cain, R., Wang, D. Y., Lohans, C. T., Wareham, D. W., Oswin, H. P., Mohammed, J., Spencer, J., Fishwick, C. W. G., McDonough, M. A., Schofield, C. J. & Brem, J. Cyclic Boronates Inhibit All Classes of β-Lactamase Antimicrob. Agents Chemother. 2017, 61, e02260-16

Brem, J., Cain, R., Cahill, S., McDonough, M. A., Clifton, I. J., Jiménez-Castellanos, J-C., Avison, M. B., Spencer, J., Fishwick, C. W. G. & Schofield, C. J. Structural Basis of Metallo-β-Lactamase, Serine-β-Lactamase and Penicillin-Binding Protein Inhibition by Cyclic Boronates. Nat. Commun. 2016, 7, 12406

Cahill, S.T., Tarhonskaya, H., Rydzik, A. M., Flashman, E., McDonough, M. A., Schofield, C. J. & Brem, J. Use of Ferrous Iron by Metallo-β-Lactamases. J. Inorg. Biochem. 2016, 163, 185-193